was successfully added to your cart.

Where cancer meets calcium — p53 crosstalk with EF-hands

By March 5, 2018Research Study

Where cancer meets calcium — p53 crosstalk with EF-hands

Mitsuhiko Ikura and Kyoko L. Yap:

S100B, an EF-hand Ca2+-binding protein, grasps the C-terminus of the tumor suppressor p53 and inhibits protein kinase C-dependent phosphorylation and acetylation of p53 in a Ca2+-dependent manner. The mode of interaction between S100B and p53 is different from the interactions seen in S100A–annexin complex structures.

Read the full articleRead the full article